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anemia bruising hemolysis hemolytic aplastic aptt arterial bleeding classification coagulation compared comparison embolism erythemas hemorrhage management obgyn obstetrics oncology pathophysiology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Diagnosis Algorithm ... delayed HTR • Drug-induced ... • PNH • Drug-induced ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... infection) - Drugs ... #Extravascular ... #Causes #differential ... #diagnosis #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Diagnosis Algorithm ... Congenital - Rare • Drugs ... • Disseminated Intravascular ... #Diagnosis #Algorithm ... #Causes #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... AIHA: warm, cold, drug ... IVIG infusion Intravascular ... #Diagnosis #causes ... classification #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Intravenous Drug ... Pregnancy • Drugs ... - Disseminated intravascular ... coagulation and other causes ... pathophysiology #hematology
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Diagnosis Algorithm ... e.g. prolonged/induced ... of uterus • Drugs ... • Disseminated intravascular ... #Diagnosis #Algorithm
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Drugs a. ... Disseminated intravascular ... #diagnosis #differential ... #hematology #coagulation
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
SLE (systemic lupus ... (disseminated intravascular ... leukaemia) - Drug-induced ... peds #pediatrics #diagnosis ... #differential #
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... Dyskeratosis congenita • Drugs ... - Cytotoxic drugs ... - β-lactam antibiotics ... Anemia #oncology #hematology
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
• Can be induced ... malignancies, and drugs ... Erythemas #comparison #table ... #differential # ... diagnosis #dermatology
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