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SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
- NON-SCARRING ALOPECIA ... ANA level above laboratory ... - Anti-dsDNA antibody ... level above laboratory ... #Diagnosis #Rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
: Non-scarring alopecia ... pericarditis • Hematologic ... Antiphospholipid antibody ... domain: Anti-dsDNA antibody ... , Anti-Sm antibody
Allopecia - Differential Diagnosis Framework for Hair Loss

Localized / Focal Hair Loss Pattern:
 • Scarring Alopecia:
Disease: Discoid lupus ... : Lupus erythematosus ... Scaling, pustules, crusts ... fungi Initial Laboratory ... • RPR • Laboratory
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm

DIFFUSE
Scarring - Irreversible-biopsy required
 • Lupus
Hair Loss (Alopecia ... Irreversible-biopsy required • Lupus ... • Discoid lupus ... #dermatology #Differential ... Diagnosis #Algorithm #causes
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Photosensitivity, Alopecia ... versus DIL • Laboratory ... Positive in 60-80% of cases ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
calcium-b) • Laboratory ... Discontinuation of causal ... Photosensitivity, Alopecia ... sle #comparison #table ... #rheumatology #
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Lupus (SLE): ... (anti-nuclear antibody ... Antiphospholipid Antibody ... glycoprotein I (ß2GP), Lupus ... #associations #table
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear Antibody ... ) • Systemic lupus ... anti-topoisomerase antibody ... #Antinuclear #Antibody ... antibodies #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
and fever) and laboratory ... and permanent alopecia ... with: • Minimal laboratory ... • Nonscarring alopecia ... vein thrombosis Hematologic
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... Allergen-specific lgE causes ... Action: Antigen-antibody ... glomerulonephritis, Systemic lupus ... types #allergy #table