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diagnosis anemia causes algorithm classification macrocytic oncology approach calculation elevatedmcv fat fatrbc index macrocytosis management mds mnemonic morphologic myelodysplasia myelodysplastic
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... Non-hemolytic: ACD, Aplastic ... , B12 deficiency ... #Differential # ... Diagnosis #hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
• Toxins • Aplastic ... Anemia • Myelodysplasia ... Nutritional deficiency ... : • B12/folate ... Algorithm #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... Reticulocytes, MCV ... • B12/Folate ... Deficiency • Aplastic ... Algorithm #Causes #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Corpuscular Volume (MCV ... ) - Differential ... (>100 fL) • B12 ... #Differential # ... Algorithm #Causes #Hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Megaloblastic: Vitamin B12 ... deficiency, Folate ... deficiency • ... #differential # ... diagnosis #causes #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic ... Anemia • Toxic ... Megakaryopoiesis • B12 ... Deficiency • ... Algorithm #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Corpuscular Volume (MCV ... ) - Differential ... • Dietary Deficiency ... and Folate Deficiency ... Algorithm #Causes #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... , GATA2 deficiency ... , CTLA4 deficiency ... #hematology #diagnosis
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Corpuscular Volume (MCV ... ) - Differential ... • Marrow Aplasia ... • Early Iron Deficiency ... Algorithm #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
loss), Vitamin B12 ... marrow failure: Aplastic ... , G6PD deficiency ... Production #Index #hematology ... #anemia #differential
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