13 results
diagnosis hematology liver lfts anemia hemolytic algorithm hepatitis agglutinin aiha antiglobulin atlas bloodcell causes chemistry cold dat direct disease elevation
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
DAT Results in Autoimmune ... , C3d ( +/- ) Paroxysmal ... #antiglobulin #test ... #DAT #Autoimmune ... #Hemolysis #hematology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - Differential ... Donath-Landsteiner HA (paroxysmal ... #Hemolytic #Anemia ... Diagnosis #Table #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Transfusion reaction, Paroxysmal ... Immune-mediated: - Autoimmune ... idiopathic) - Autoimmune ... Extravascular #Causes #differential ... #diagnosis #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Inflammatory and Autoimmune ... erythematosus • HLH • Paroxysmal ... Antibody-mediated hemolysis ... #Diagnosis #Hematology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
- Differential ... → liver test abnormalities ... Other: NAFLD, Autoimmune ... Diagnosis #hepatology ... #algorithm #Transaminitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Liver Function Tests ... (LFTs) - Differential ... Drug-induced liver injury ... #Diagnosis #hepatology ... #transaminitis
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... ) vs Indirect (Hemolytic ... Hepatocellular injury ... LFTs #Elevation #Transaminitis ... #diagnosis #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... 2-5x normal - Hemolysis ... #hepatology #LFTs ... #transaminitis ... #differential #diagnosis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Membrane): - Autoimmune ... Laboratory Tests ... #Differential # ... Diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... younger pts) Differential ... macroglobulinemia Paroxysmal ... • Diagnostic Test ... #anemia #hematology
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