23 results
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Syndrome and Acute ... ) Three syndromes ... (Hemolysis, Elevated ... Liver tests, Low ... #hematology #diagnosis
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... syndrome (ST-HUS ... anemia" • HELLP ... #differential #diagnosis ... #hematology #hemolysis
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... Causes #Workup #Hematology ... #Diagnosis * ... GrepMed Recommended Text
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Pregnancy Three syndromes ... (Hemolysis, Elevated ... Liver tests, Low ... #AFLP #Obstetrics ... #OBGyn #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... coagulation (DIC) - HELLP ... syndrome - ... uremic syndrome ... #hematology #anemia
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Liver Function Tests ... - Differential Diagnosis ... Wilsons, Pregnancy - AFLP ... , HELLP • Moderate ... #diagnosis #hepatology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Diagnosis Framework ... TTP, HUS, DIC, HELLP ... Drug-associated, PCH, Evans Syndrome ... Laboratory Tests ... #hematology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
, no necrosis HELLP ... Syndrome (Hemolysis ... Disease #Pregnancy #hepatology ... #differential #diagnosis ... #icp #HELLP #AFLP
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... blood loss, Acute hemolysis ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... #Algorithm #hematology
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
Algorithm for workup ... thrombocytopenic purpura/hemolytic ... uremic syndrome ... thrombocytopenia, Hematology ... 2012, p 193 #Diagnosis