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diagnosis management rheumatology sle erythematosus algorithm antiphospholipid causes cerebritis cns comparison dermatology differential druginduced emergencies hemophagocytic hlh hypercoagulable lymphohistiocytosis neurology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... 40, F:M 9:1 • Clinical ... Manifestations: Malar rash ... • Immunologic Workup ... Positive in 60-80% of cases
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Autoimmune Vasculitis (lupus ... : - ITP - APLS ... deficiency Work ... #Causes #dermatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... Malignancy (e.g. hematologic ... Clinical Features ... Antiribosomal P, APLA
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... (SLE) Clinical ... Demyelinating Syndrome ... autoantibodies that will cause ... (for secondary APS
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... NPSLE rare, Malar rash ... • Immunologic Workup ... Discontinuation of causal ... months to years) Systemic
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
(APLS) Testing ... - 1 or more clinical ... maternal chromosomal causes ... excluded Testing: • Lupus ... #hematology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
): - Hematologic ... Treat underlying cause ... - CRS: fever, rash ... AML (~20 %) and APL ... Emergencies #Oncology #HemeOnc
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
caused by uncontrolled ... of the immune system ... Treatment Approach ... Diagnosis #Management #Hematology ... #HemeOnc
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