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diagnosis rheumatology management differential erythematosus systemic algorithm causes dermatology classification druginduced thrombocytopenia activation cerebritis cns comparison cryoglobulinemia cryoglobulins damage exposure
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Lupus (DIL): ... to 1:1 F:M • Clinical ... NPSLE rare, Malar rash ... SCLE-DIL (terbinafine ... Discontinuation of causal
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
40, F:M 9:1 • Clinical ... Manifestations: Malar rash ... versus DIL • ... Positive in 60-80% of cases ... life-threatening • Treatment
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Autoimmune • ITP • SLE ... Non-lmmune: • HELLP Syndrome ... • TTP/HUS • DIC ... • Vasculitis ... #Causes #Hematology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... (SLE) General: ... Photosensitivity, Butterfly rash ... , Vasculitis, Purpura ... Demyelinating syndromes
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Diagnosis Algorithm ... fulminans - DIC ... (lupus, RA, Sjogren's ... #Causes #dermatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... ANCA-associated vasculitis ... Clinical Features ... vein thrombosis Hematologic
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Approach to Thrombocytosis ... Rebound effect from treatment ... Rheumatologic, Vasculitides ... Kawasaki, Nephrotic syndrome ... Glucocorticoids, IL
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... ) Clinical Manifestations ... Demyelinating Syndrome ... autoantibodies that will cause ... Erythematosus #SLE
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... : • Clinical triad ... (e.g. systemic lupus ... erythematosus (SLE
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Petechial or purpuric rash ... SJIA], systemic lupus ... erythematosus [SLE ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
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