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differential causes hemolytic intravascular atlas cold deficiency disease ferritin iron key mcv morphology platelets rbc testing thrombocytosis workup
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... uremic syndrome ... . primary cold agglutin ... #hematology #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Diagnosis Algorithm ... anemia • ... Differential #Diagnosis ... #Algorithm #Causes ... #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Syndrome (CAS): ... Diagnosis: • hemolytic ... anemia • Cold ... the RBCs causing intravascular ... #anemia #hematology
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Algorithm Labs ... (not extravascular ... ) hemolysis, Intensive ... Gastrectomy, WHDA syndrome ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle ... Agglutination - Cold agglutinins ... #Diagnosis #Algorithm ... #workup #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
- Differential Diagnosis ... Algorithm Low ... • Bleeding • Hemolysis ... #MCV #Classification ... #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Myelodysplastic syndrome ... spherocytosis, Hemolytic ... uremic syndrome ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... #Diagnosis #causes ... #classification ... #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... blood loss, Acute hemolysis ... , deficiency anemia ... Kawasaki, Nephrotic syndrome ... #Algorithm #hematology
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