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diagnosis hematology hemolytic extravascular intravascular lfts thrombocytopenia abnormal bilirubinemia classification comparison elevated hepatitis injury jaundice liver liverenzymes liverfunctiontests obstetrics pregnancy
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... coagulation (DIC) - HELLP ... uremic syndrome (HUS ... #differential # ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... - Differential ... anemia • ... MAHA (TTP, DIC, HUS ... #Causes #Hematology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
Pregnancy - TTP/HUS ... of Pregnancy (AFLP ... (Hemolysis, Elevated ... child * Severe cases ... #table #comparison
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... Diagnosis Algorithm ... , HELLP • Moderate ... Drugs, Infection, Sepsis ... #diagnosis #hepatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... thrombocytopenia - DIC, TTP, HELLP ... , HUS, aHUS, mechanical ... #Anemia #Differential
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Diagnosis Algorithm ... • Pregnancy - AFLP ... , HELLP Moderate ... Others #LFTs #Hepatology ... #Causes
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... • MAHA: TTP, HUS ... , DIC, HELLP, AS ... #Anemia #Differential
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential ... Megakaryopoiesis • Aplastic Anemia ... Non-lmmune: • HELLP ... Syndrome • TTP/HUS ... #Causes #Hematology
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Jaundice - Differential ... Diagnosis Algorithm ... Production • Hemolysis ... Hepatic Uptake • Sepsis ... #Causes #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... Diagnosis Algorithm ... Vascular Causes ... • Pregnancy: HELLP ... #hepatology
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