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diagnosis hematology causes algorithm management anemia blood extravascular hemolytic microangiopathy product reactions thrombocytopenia thrombotic ttp bilirubinemia classification coagulation comparison dermatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
thrombocytopenic purpura ... uremic syndrome (HUS ... #Hemolytic #Intravascular ... #Causes #differential ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
and Intravascular ... Hemolysis - Differential ... MAHA (TTP, DIC, HUS ... Differential #Diagnosis ... Algorithm #Causes #Hematology
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table • Thrombotic Thrombocytopenic Purpura (TTP)
Microangiopathy (TMA) - Differential ... Diagnosis Table ... Thrombocytopenic Purpura ... Microangiopathy #TMA #hematology ... #differential #
Thrombotic Microangiopathy - TTP VS HUS Big picture points : Often hard to differentiate the two entities,
Often hard to differentiate ... thrombocytopenic #purpura ... HemolyticUremicSyndrome #HUS ... Comparison #Diagnosis #Table ... #Hematology
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic
TTP/HUS indicates ... thrombocytopenic purpura ... /hemolytic uremic ... thrombocytopenia, Hematology ... #Diagnosis #Differential
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... IVIG infusion Intravascular ... • MAHA: TTP, HUS ... classification #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... disease - DIC/TTP/HUS ... - Hemolytic ... : • DIC, TTP/HUS ... #Differential #
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Jaundice - Differential ... Production • Hemolysis ... Hepatic Uptake • Sepsis ... Post-Hepatic - Usually has ... Algorithm #Causes #Hepatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Thrombocytopenic Purpura ... reflection of intravascular ... hemolysis Platelet ... WBC count and differential ... Diagnosis #Workup #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... history of trauma, sepsis ... Petechiae • Purpura ... DDX: • TMA’s (HUS ... - MAHA: TTP/HUS
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