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diagnosis hematology causes hemolytic microscopy algorithm analysis atlas bloodcell calculation classification clinical dehydrogenase elevated extravascular hodgkins index interpretation intravascular laboratory
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... syndrome (ST-HUS ... Drug-induced thrombotic microangiopathy ... anemia" • HELLP ... #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
hemolytic anemia ... uremic syndrome (HUS ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... • Peripheral blood ... hemolytic anemia ... (TTP, HUS, DIC, ... #Anemia #Differential
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood ... Schistocytes: Microangiopathic ... hemolytic anemia ... DIC, TTP, HUS) ... Smear #Analysis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Retroperitoneal, Uterine • Hemolysis ... : Autoimmune, Microangiopathic ... hemolytic anemia ... Production #Index #hematology ... #anemia #differential
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... disease, McLeod blood ... Schistocyte: Microangiopathic ... Hemolytic Anemia ... RBC #Morphology #differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... - MAHA: TTP, HUS ... Defects: Sickle cell anemia ... - Peripheral Blood ... Diagnosis #hematology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... the serum that has ... deficiency of red blood ... - Acquired: Microangiopathic ... hemolytic anemia
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
persons • It has ... Weight loss • Anemia ... nodosum • Immune hemolytic ... anemia • Pain ... Immunohistochemical studies (to differentiate
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