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diagnosis algorithm liver causes acute inherited lfts aki apml arterial bilirubin bilirubinemia chemistry comparison congenital cryofibrinogenemia defects differentiation embolism enzymes
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Jaundice - Differential ... Hepatic Uptake • Sepsis ... Post-Hepatic - Usually has ... Dilatation on Ultrasound ... Algorithm #Causes #Hepatology
Hepatorenal Syndrome (HRS) - Diagnostic Criteria HRS-AKI (Acute: previously known as HRS Type 1) • ↑ Creatinine
Hepatorenal Syndrome ... structural kidney injury ... No haematuria, Normal ... renal ultrasound ... HRSAKI #HRSNAKI #hepatology
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Thrombocytopenia - Differential ... - Bacterial: Sepsis ... Microangiopathy: DIC, TTP, HUS ... antiphospholipid syndrome ... Diagnosis #Framework #hematology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
of Acute Liver Injury ... - Differential ... obstruction, HELLP Syndrome ... • Infectious: Sepsis ... Acute #algorithm #hepatology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... investigations abnormal ... pressure • TTP / HUS ... • Cardio-renal syndrome ... Acute #Kidney #Injury
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... - MAHA: TTP, HUS ... Drug-associated, PCH, Evans Syndrome ... Blood Smear ↑ abnormal ... #Diagnosis #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... vein: Budd-chiari syndrome ... function may be abnormal ... • Gilbert's syndrome ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
- If both are normal ... of ALP • Near normal ... • Gilbert's syndrome ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
hyperbilirubinemia syndrome ... • Has a UGT1A1 ... of about 30% of normal ... hemolysis or liver injury ... Congenital #bilirubin #hepatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... presence of metabolic syndrome ... mellitus; USS, ultrasound ... #Algorithm #Hepatology ... Liver #Enzymes #Differential
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