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Hypocalcemia - Workup Algorithm

Dr Nikhil Lohiya - NEPHKIDS 2020 @NEPHKIDS1

#Hypocalcemia #Workup #Algorithm #differential #diagnosis #endocrinology #causes
Workup #Algorithm #differential ... #diagnosis #endocrinology ... #causes #calcium
Hypocalcemia Laboratory Evaluation

Serum levels of PTH, phosphorus, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D can help differentiate between
dihydroxyvitamin D can help differentiate ... Hypoparathyroidism - Calcium-sensing ... deficiency - Chronic ... Hyperparathyroidism #Diagnosis #Endocrinology ... #Differential
Hypercalcemia Workup and Differential Diagnosis Framework
1) Determine whether PTH-dependent
2) Assess for other hormonal causes
3) Assess for
Hypercalcemia Workup and Differential ... other hormonal causes ... for non-hormonal causes ... Diagnosis #algorithm #endocrinology ... #calcium
Causes of Constipation - Differential Diagnosis Framework
 • Motility: Diet, IBS-C, Colonic inertia, Pelvic floor disorders,
Causes of Constipation ... - Differential ... Diuretics, Iron, Calcium ... e.g. fissure), Chronic ... #Diagnosis #Causes
Causes of Hypercalcemia
Hypercalcemia due to increased bone Ca2+ resorption:
 • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... Hypercalcemia #Causes ... #differential # ... diagnosis #calcium ... #high #endocrinology
Causes of Iron Deficiency - Differential Diagnosis Algorithm
 • Blood loss: GI (cancer, ulcer, IBD), GU
Causes of Iron Deficiency ... - Differential ... Increased hepcidin: Chronic ... Zinc, Manganese, Calcium ... #Diagnosis #Causes
Hypercalcemia - Differential Diagnosis Algorithm
Elevated PTH (High or normal):
 • Primary Hyperparathyroidism
 • Familial Hypocalciuric Hypercalcemia
Low
Hypercalcemia - Differential ... Bony Mets - Calcium ... Hypercalcemia #Differential ... Diagnosis #Algorithm #causes ... #endocrinology
Causes of Hypocalcemia - Differential Diagnosis Algorithm
 • Extravascular: Pancreatitis, surgery, acute phosphate intake and renal
Causes of Hypocalcemia ... - Differential ... Drug induced: Calcium ... Pseudohypoparathyroidism, Chronic ... #Hypocalcemia #Differential
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Thrombocytosis - Differential ... • Infection/Sepsis ... Myelofibrosis • Chronic ... Thrombocytosis #Differential ... #Diagnosis #causes
Causes of Hypercalcemia
Parathyroid gland structure-related
 • Primary hyperparathyroidism
 • Parathyroid adenoma
 • Parathyroid hyperplasia
 • Parathyroid
Causes of Hypercalcemia ... Lithium use • Calcium-sensing ... Pheochromocytoma Chronic ... #endocrinology ... #diagnosis #differential