21 results
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... disease, liver ... Kidney Failure ... #Chronic #Liver ... #Hepatology #gastroenterology
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
of Sickle Cell Disease ... Supportive with treatment ... liver failure ... Liver transplant ... Hepatobiliary #hepatology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
, chronic kidney ... , chronic kidney ... , and chronic kidney ... , chronic kidney ... Tolvaptan) • Treatment
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Liver Failure ( ... of cholestatic disease ... disease: > 2 ... • NASH, Chronic ... #differential #Hepatology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
kidney disease, ... Acute blood loss ... : Alcohol use, Liver ... disease (independent ... diagnosis #causes #hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Skin involvement, Kidney ... non-essential drug/HDS treatments ... disease, Hepatic ... dechallenge • Acute ... Diagnosis #Algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... • NASH, Chronic ... injury: > 3 • Chronic ... cardiac muscle, kidneys ... diagnosis #algorithm #hepatology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Failure - Elevated ... —100-fold with acute ... liver failure; ... liver disease, ... LiverFailure #Hepatic #Hepatology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
• Anemia of chronic ... kidney disease, ... • Bone marrow failure ... Index > 3: • Acute ... Production #Index #hematology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
from subclinical disease ... to acute liver ... failure ... - Symptoms of chronic ... Diagnosis #Management #Hepatology