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diagnosis management differential hepatology algorithm anemia causes oncology workup leukemia liver product reactions aclf alcoholic alkaline alp approach arthritis basophilia
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... : Acute blood loss ... Rebound effect from treatment ... • Infections: Chronic ... Diagnosis #Algorithm #hematology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... underlying liver disease ... Kidney Failure ... #Chronic #Liver
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm Blood ... Loss • Acute ... on Smear • Chronic ... Disease • Marrow ... Algorithm #Causes #Hematology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
kidney disease, ... kidney disease, ... kidney disease ... kidney disease ... Prevention of blood
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
kidney disease, ... Acute blood loss ... , Anemia of chronic ... Alcohol use, Liver disease ... diagnosis #causes #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
the peripheral blood ... kidney disease, ... • Bone marrow failure ... Index > 3: • Acute ... Production #Index #hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
the total white blood ... Disorders: • Chronic ... translocation • Acute ... Colitis and Crohn’s Disease ... Diagnosis #causes #hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Failure ( ... of cholestatic disease ... Alcoholic liver disease ... > 2 • NASH, Chronic ... intestines, White blood
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... lesions, meninges, kidneys ... hypergammaglobulinemia, ↑ acute ... maintenance with GCs ... #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... the peripheral blood ... extramedullary disease ... Philadelphia - BCR-ABL ... #Leukemia #Hematology
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