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diagnosis hematology differential management algorithm product transfusion anemia aplastic basophilia basophils classification diffuse disorders eosinophil eosinophilia hodgkins lad leukemia lymphadenopathy
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
the total white blood ... released during an allergic ... reaction or asthma ... Or Inflammatory Reactions ... #hematology #basophils
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Infectious • EBV ... • Acne • Allergy ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
workup, including BM ... hematologic: Acute blood ... syndrome, POEMS • Reaction ... post-splenectomy, Exercise, Allergic ... reactions Matthew
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
• Peripheral blood ... for secondary causes ... eosinophilia (common causes ... are asthma, allergy ... , drug reaction,
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
• Allergic reaction ... Causes purpura & ... TRALI): Leading cause ... more likely to cause ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
- Allergic ... Causes purpura & ... TRALI): Leading cause ... more likely to cause ... diagnosis #management #hematology
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care TRICC - NEJM 1999 -
NEJM 1999 - ICU FOCUS ... Transfusing blood ... Blood saves lives ... unnecessary and cause ... /vmoitra) #EBM
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Toxic injury to BM ... and petechiae Causes ... result from low blood ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
replacing the BM ... Idiosyncratic drug reactions ... Idiosyncratic drug reactions-most ... including white blood ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... • Cytopenia -> BM ... -> AML: Blast crises ... #Leukemia #Hematology ... #Oncology #Diagnosis
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