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diagnosis management differential workup causes deficiency anemia blood hemophagocytic hlh infections lymphohistiocytosis oncology pancytopenia pathophysiology product reactions activation acute b12
Risk Factors and Signs of Copper Deficiency Risk Factors: • Gastrointestinal: Previous upper bowel resection/bariatric surgery, Inflammatory
, Chronic diarrhoea ... , Short bowel syndrome ... dental fixatives, Treatment ... • Nutritional: ... Musculoskeletal: Low
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Production - Flow ... HLH syndrome 5. ... Drugs Nutritional ... Metastatic Disease ... #Hematology
Causes of Polycythemia (Erythrocytosis) - Differential Diagnosis Algorithm Relative - Normal RBC Mass / Decreased Plasma Volume
Differential Diagnosis Algorithm ... • Burns • Diarrhea ... JAK-2 Positive - Low ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Production - Flow ... HLH syndrome 5 ... Drugs Nutritional ... Metastatic Disease ... #Hematology
Refeeding Syndrome Overview What Is It? • Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
initiation of nutrition ... due to chronic disease ... Palpitations • Diarrhea ... hyperparathyroidism Treatment ... , K, Mg2+) • Slow
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease ... Kawasaki, Nephrotic syndrome ... #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Infectious diarrhea ... 300 mg/dL) • Low ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Differential Diagnosis Algorithm ... • Pancreatic Disease ... Myelodysplastic Syndromes ... • Liver Disease ... #Causes #Hematology
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Differential Diagnosis Algorithm ... Gastrectomy, WHDA syndrome ... Structural: Celiac disease ... Pregnancy, Lactation, Low ... #ferritin #hematology
Irritable Bowel Syndrome (IBS) - Diagnosis and Workup Summary Use a positive diagnostic strategy with minimal testing.
Irritable Bowel Syndrome ... /o red flags - Low ... • If Diarrhea: ... Rule out celiac disease ... inflammatory bowel disease
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