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diagnosis differential hematology erythrocytosis generalized oncology pruritus systemic common cvid disorders enlarged eosinophil eosinophilia fever focal hypogammaglobulinemia immunecompromised immunocompromised immunodeficiency
Erythrocytosis - Polycythemia Differential Diagnosis Algorithm Elevated Hemoglobin: • Males: Hb > 16.5 g/dL/HCT ≥ 49% •
Differential Diagnosis Algorithm ... Vera Secondary ... Acquired Causes: ... Cardiac/pulmonary disease ... #hematology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Diagnosis Algorithm ... an underlying cause ... Better call hematology ... As with many disease ... #workup #hematology
Causes of Polycythemia (Erythrocytosis) - Differential Diagnosis Algorithm Relative - Normal RBC Mass / Decreased Plasma Volume
Causes of Polycythemia ... Differential Diagnosis Algorithm ... • Burns • Diarrhea ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Causes of Splenomegaly ... Differential Diagnosis Algorithm ... disorders (eg. polycythemia ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Differential Diagnosis Algorithm ... thrombocytosis • Polycythemia ... disorders • Celiac disease ... #Causes #Hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Systemic and Primary Causes ... • Leukemia • Polycythemia ... Pruritus #primary #secondary ... #generalized #dermatology ... #causes
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Disorders Testing Algorithm ... evaluation or workup ... • Screen for secondary ... (common causes ... Differential #diagnosis #hematology
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
Causes of Localized ... Differential Diagnosis Algorithm ... • Kikuchi Disease ... Tularemia • Secondary ... #Causes #Hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Cholestatic liver disease ... • Leukemia • Polycythemia ... #Pruritus #secondary ... #generalized #dermatology ... #causes
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... • Chronic lung disease ... • Infectious diarrhea ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
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