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differential management rheumatology hemophagocytic lymphohistiocytosis algorithm causes criteria oncology treatment comparison criticalcare dermatology infectiousdiseases rash signs syndrome table blood erythematosus
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Clinical Features: Fever ... IL-2 receptor Diagnostic ... Criteria): Molecular diagnosis ... 8 criteria: • Fever ... #hematology #criteria
Shock - Differential Diagnosis by Classification Hypovolemic (Intravascular volume depletion) - Hemorrhagic • Trauma
Shock - Differential ... Diagnosis by Classification ... • Severe diarrhea ... #Differential #Diagnosis ... #Classification
Bedside Classification of Shock Hypovolemic shock - Vomiting, diarrhea, overdiuresis - Hemorrhage (GI, peritoneal, RP) Distributive shock
Bedside Classification ... shock - Vomiting ... , diarrhea, overdiuresis ... #Classification ... Comparison #Table #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Presentation / Diagnosis ... Diagnosis via genetic ... following: • Fever ... Infection should be diagnosed ... management #treatment #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... • Clinical: fever ... hemophagocytosis = additional diagnostic ... Lymphohistiocytosis #diagnosis ... treatment #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lymphohistiocytosis (HLH ... disease • Periodic fever ... - Nonremitting fever ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Fever and Rash - Differential Diagnosis Framework • Viral: Measles, Infectious Mono (EBV, CMV), Acute HIV,
Fever and Rash - ... Differential Diagnosis ... diseases, Toxic shock ... #Differential #Diagnosis ... #dermatology
Algorithm for the Evaluation of Acute Diarrhea (< 7 days) Are the following present? 1.
Evaluation of Acute Diarrhea ... Ova and parasite ... Bloody diarrhea, ... fever, abdominal ... algorithm #workup #diagnosis
Clinical Manifestations of Serotonin Syndrome • Ophthalmologic: Mydriasis, Ocular clonus (slow horizontal movements) • Gastrointestinal: Diarrhea,
Gastrointestinal: Diarrhea ... : Tachycardia, Fever ... , Late stages (shock ... spectrum #signs #diagnosis
Shock Overview A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
Shock Overview ... : GI (vomiting/diarrhea ... #Classification ... #diagnosis #management ... differential #causes #classification
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