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diagnosis management differential lupus vasculitis blood classification hemophagocytic lymphohistiocytosis product reactions summary systemic thrombocytopenia activation aortitis cerebritis clues cns comparison
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Systemic lupus erythematosus ... [SLE], AOSD) • ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Differential Diagnosis Algorithm ... Autoimmune • ITP • SLE ... Alloimmune • anti-HLA ... #Causes #Hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Positive in 60-80% of cases ... life-threatening • Treatment ... lupus #Systemic #Erythematosus ... Management #Summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... Autoimmune diseases: SLE ... Treatment: • ... diagnosis #management #treatment ... #summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Systemic Lupus Erythematosus ... (SLE) Clinical ... autoantibodies that will cause ... #SLE #CNS #neurology ... #rheumatology #
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Systemic lupus erythematosus ... (SLE), Sarcoidosis ... , HLA-B27-related ... (SPA) • Other Causes ... Differential #Diagnosis #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
constitutional symptoms • Treatment ... Discontinuation of causal ... Systemic Lupus Erythematosus ... life-threatening • Treatment ... comparison #table #rheumatology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
9) Unexplained fever ... children (pediatric SLE ... lupus #diagnosis #sle ... #erythematosus # ... rheumatology
Kawasaki Disease (KD) - Diagnosis and Management Summary Kawasaki Disease (KD) is the most common vasculitis of
Presentation: • Fever ... , Cough • +/-Nausea ... , vomiting, diarrhea ... KD #vasculitis #rheumatology ... diagnossi #management #treatment
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Differential Diagnosis Algorithm ... Bronchitis • Chronic Diarrhea ... Infection #Fever ... #Causes #Hematology
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