107 results
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Autoimmune Hemolytic Anemia ... (AIHA) Pathophysiology ... or negative - Smear ... Autoimmune #Hemolytic #Anemia ... #Pathophysiology
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... - Differential ... Algorithm Signs of anemia ... Abnormal peripheral smear ... #Differential #
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Autoimmune Hemolytic Anemia ... DIAGNOSE AIHA • Anemia ... C3d • Blood smear ... : Differential → ... Autoimmune #Hemolytic #Anemia
Causes of Aplastic Anemia

#Aplastic #Anemia #Causes #Pathophysiology #Pathology #Treatment #Management #Differential
Causes of Aplastic Anemia ... #Aplastic #Anemia ... #Causes #Pathophysiology ... #Pathology #Treatment ... #Management #Differential
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... - Differential ... Deficiency • Aplastic Anemia ... • Anemia of Chronic ... Non-lmmune #Anemia
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... Peripheral blood smear ... → Sickle Cell anemia ... Microangiopathic hemolytic anemia ... UnremarkableLab #Hemolytic #Anemia
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... Normal Blood Smear ... • Pernicious Anemia ... • Pernicious Anemia ... #Macrocytic #Anemia
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Iron-deficiency anemia ... Sideroblastic anemia ... Myelodysplastic syndrome ... Hemolytic uremic syndrome ... key #diagnosis #differential
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell anemia ... Peripheral Blood Smear ... #Hemolysis #Differential
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
blood cell count (anemia ... • Aplastic Anemia ... Megaloblastic Anemia ... Myelophthisic Anemia ... dyserythropoietic anemia