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endocrinology diagnosis differential binders calcium causes chondrocalcinosis comparison cppd disease highcalcium hormone hormones malignancy nephrology osteoblasts osteoclasts parathormone parathyroid pharmacology
Hypercalcemia - Hormones and Pathophysiology Calcitriol: • Bones: Enhances mineralization • GI Tract: ↑ Ca2+
Hypercalcemia - ... Hormones and Pathophysiology ... : ↑ Bone resorption ... +, ↓ PO4- #Hypercalcemia ... #Hormones #Pathophysiology
Hypercalcemia of Malignancy - Pathophysiology PTH-mediated • Parathyroid cancer • Ectopic production: Small cell lung cancer, ovarian
Hypercalcemia of ... intestinal calcium absorption ... in the bone • ... in the bone • ... Differential #Diagnosis #algorithm
Parathyroid Hormone (PTH) Effect in Calcium and Phosphorus Calcium - Net Effect Hypercalcemia: ↑ intestinal
Calcium - Net Effect Hypercalcemia ... ↑ intestinal absorption ... ↑ bone reabsorption ... Hypophosphatemia: ↑ bone ... Calcium #Phosphorus #pathophysiology
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Hypercalcemia - ... Differential Diagnosis Algorithm ... Miscellaneous - Bone ... , Bony Mets ... Differential #Diagnosis #Algorithm
Characteristics of Commonly Used Phosphate Binders Aluminum - Potent and effective - Useful for
- No systemic absorption ... risk of adynamic bone ... increased risk of low bone ... of iron that may ... decrease iron and
Hypercalcemia - Differential Diagnosis Algorithm Primary Hyperparathyroidism • Adenoma • Hyperplasia • MEN 1 and 2A Tertiary Hyperparathyroidism
Differential Diagnosis Algorithm ... Cytokine-Mediated Bone ... Resorption (e.g ... Lymphomas) Metastatic Bone ... Differential #Diagnosis #Algorithm
Bone resorption and the relationship between osteoblasts and osteoclasts. RANK is expressed on the osteoclasts,
Bone resorption ... that facilitate resorption ... an increase in ion ... #Pathophysiology ... #Resorption #RANKL
Pseudogout: pathogenesis and clinical findings - Idiopathic (vast majority of cases) -> Mechanism unknown - Familial
incr gut Ca2+ absorption ... is inhibited by iron ... phosphorous in bones ... Signs #Symptoms #Pathophysiology
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