9 results
diagnosis signs symptoms differential endocrinology hypercalcemia arthropathy causes charcotjoint chondrocalcinosis complications cppd disease disruptors fracture glucocorticoids healing highcalcium hyperferritinemia msk
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
action -> Decr Ca2+ Absorption ... -> Reduced Bone ... Formation, Increased Bone ... Resorption, Decreased ... #Osteoporosis #pathophysiology
Bone resorption and the relationship between osteoblasts and osteoclasts. RANK is expressed on the osteoclasts,
Bone resorption ... an increase in ion ... #Pathophysiology ... #Osteoclasts #Bone ... #Resorption #RANKL
Hypercalcemia of Malignancy - Pathophysiology PTH-mediated • Parathyroid cancer • Ectopic production: Small cell lung cancer, ovarian
Hypercalcemia of Malignancy ... - Pathophysiology ... intestinal calcium absorption ... in the bone • ... Differential #Diagnosis #algorithm
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
be used by the bone ... cause increased GI absorption ... of iron. ... Malignancy - 24% ... Hematologic Malignancy
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
forms bony callus ... coupled bone remodeling ... Insufficient Ca2+ & PO4- absorption ... from GI tract, bone ... #msk #Staging #pathophysiology
Hypercalcemia - Differential Diagnosis Algorithm Primary Hyperparathyroidism • Adenoma • Hyperplasia • MEN 1 and 2A Tertiary Hyperparathyroidism
Differential Diagnosis Algorithm ... /lsotretinoin Malignancy ... Cytokine-Mediated Bone ... Resorption (e.g ... Lymphomas) Metastatic Bone
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Complications Abnormal Osteoclasts ... resorption, Incr ... (abnormal) bone ... resorption, Incr ... PagetsDisease #pathophysiology
Pseudogout: pathogenesis and clinical findings - Idiopathic (vast majority of cases) -> Mechanism unknown - Familial
incr gut Ca2+ absorption ... is inhibited by iron ... phosphorous in bones ... Signs #Symptoms #Pathophysiology
Charcot Joint - Neuropathic Arthropathy: Pathogenesis and Clinical findings • Impaired joint protection -> abnormal joint
cytokines act on osteoclasts ... periarticular bone ... resorption -> On ... #Arthropathy #pathophysiology
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