17 results
Pharmacology of diuretics

Acetazolamide, Loop diuretics, Thiazide‐like diuretics, MRA, Amiloride

Site of Action, Maximum Dose, Half-Life, Onset, Bioavailability,
Acetazolamide, Loop ... Half-Life, Onset, Bioavailability ... , Absorption # ... #Comparison #Table ... HalfLife #Dosing #Loop
Causes of Polyuria - Differential Diagnosis
Excess Intake of Water:
 • Primary polydipsia (a.k.a. "psychogenic polydipsia")
 •
Causes of Polyuria ... a.k.a. osmotic diuresis ... : Conventional diuretics ... Defect in Tubular Reabsorption ... #nephrology
Polyuria - Differential Diagnosis Algorithm
Urine Output > 3L /day
Water Diuresis (Urine Osm <100 mOsm/kg)
 • Primary
Polyuria - Differential ... Diagnosis Algorithm ... solute load #Polyuria ... Differential #Diagnosis #Algorithm ... #causes #nephrology
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Metolazone Loop ... • Inhibit Na+ reabsorption ... #Pharmacology #nephrology ... #conversion #loop ... #thiazide #classes
Causes of Polyuria - Differential Diagnosis Algorithm
Polyuria - Urine Output > 3L/day, Increased Urine Volume (>2ml/min)
Osmotic
Causes of Polyuria ... Differential Diagnosis Algorithm ... /min) Osmotic Diuresis ... #Nephrology #Differential ... #Causes
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
organic acids and bases ... acid and most diuretics ... limb of Henle's loop ... limb of Henle's loop ... Pathophysiology #Tubules #Table
Causes of Hypernatremia - Differential Diagnosis Algorithm
Hypernatremia - Excess free water loss, Serum Sodium >145 mmol/L
High
Causes of Hypernatremia ... administration • Osmotic diuresis ... (see Polyuria scheme ... Hypernatremia #Nephrology ... #Causes
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic ... • Thiazide or loop ... diuretics after ... Differential #Diagnosis #Causes ... #nephrology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Differential Diagnosis Algorithm ... • HTN Absent: Loop ... and thiazide diuretics ... #causes #potassium ... #low #nephrology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
Differential Diagnosis Algorithm ... Clinicians should also look ... Post-hypercapnia • Diuretics ... differential #diagnosis #algorithm ... #causes #nephrology