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diagnosis differential hyperkalemia high algorithm hematology management nephrology classification product reactions addisons adrenal anemia coagulation dic disease disseminated dm2 elevation
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... Elevation == Decreased ... -12, or folate deficiency ... turnover • Acute blood ... loss • Hemolytic
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... Transfusion Thresholds ... recipients w/ IgA deficiency ... Causes purpura & ... potassium from
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Crush injury • Blood ... • Recent IV potassium ... Blood transfusion ... differential #diagnosis #causes ... #potassium #high
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... • Peripheral blood ... DAT (-) → G6PD Deficiency ... disease, drugs, transfusions ... Diagnosis #Algorithm #causes
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Crush injury • Blood ... • Recent IV potassium ... Blood transfusion ... differential #diagnosis #causes ... #potassium #high
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... recipients w/ IgA deficiency ... Causes purpura & ... TRALI): Leading cause ... potassium from
Hyperkalemia: Diagnostic algorithm Decreased renal potassium excretion • Acute renal failure • Chronic renal failure • Drugs Increased
Diagnostic algorithm Decreased ... renal potassium ... diet • Blood ... transfusion • ... Tumor lysis/hemolysis
Causes of Hyperkalemia Pseudohyperkalemia - Tourniquet use - Hemolysis (in vitro) - Leukocytosis - Thrombocytosis Intra- to extracellular
Causes of Hyperkalemia ... drugs - Transfusion ... of aged blood ... - Hemolysis (in ... tissue necrosis Decreased
Causes of HyperKalemia - Differential Diagnosis Increased extracellular K+: • Tissue injury • Hemolysis • Rhabdomyolysis •
Causes of HyperKalemia ... Tissue injury • Hemolysis ... dietary intake • Blood ... transfusion • ... of injection Decreased
Causes of Hyperkalemia - Differential Diagnosis Framework • Cellular Shift: - Exercise
Causes of Hyperkalemia ... - Insulin deficiency ... Crush injury, Hemolysis ... hyperkalemia: Blood ... #potassium #high
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