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Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care TRICC - NEJM 1999 -
Thresholds in Critical ... blood is a liquid ... Blood saves lives ... unnecessary and cause ... #Thresholds #Hematology
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... Elevation == Decreased ... Hypertriglyceridemia • Uremia High ... turnover • Acute blood ... loss • Hemolytic
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... Transfusion Thresholds ... Causes purpura & ... TRALI): Leading cause ... High mortality.
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... Causes purpura & ... TRALI): Leading cause ... High mortality. ... more likely to cause
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... • Peripheral blood ... Immune mediated hemolysis ... disease, drugs, transfusions ... Diagnosis #Algorithm #causes
Causes of HyperKalemia - Differential Diagnosis Increased extracellular K+: • Tissue injury • Hemolysis • Rhabdomyolysis •
Tissue injury • Hemolysis ... glycosides • High ... dietary intake • Blood ... transfusion • ... of injection Decreased
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... Crush injury • Blood ... Blood transfusion ... differential #diagnosis #causes ... #potassium #high
Hyperkalemia: Diagnostic algorithm Decreased renal potassium excretion • Acute renal failure • Chronic renal failure • Drugs Increased
Diagnostic algorithm Decreased ... Potassium-rich diet • Blood ... transfusion • ... Tumor lysis/hemolysis ... Normal, Renin High
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... Crush injury • Blood ... Blood transfusion ... differential #diagnosis #causes ... #potassium #high
Hypoxemic Respiratory Failure - Differential Diagnosis Framework DECREASED INSPIRED OXYGEN • Low PATM Can decrease first part
Diagnosis Framework DECREASED ... • Low PATM Can decrease ... : High altitude ... : Decreased respiratory ... • Occurs when blood
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