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diagnosis hematology management differential thrombocytopenia bruising purpura table aflp algorithm anemia bleeding blood comparison dermatology hellp intravascular nonbleeding obstetrics pediatrics
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care TRICC - NEJM 1999 -
Thresholds in Critical ... unnecessary and cause ... Transfusions should ... Transfusions are ... #Thresholds #Hematology
Indications for Transfusion of Platelets in Neonates #Management #Peds #Pediatrics #Platelets #Transfusion #Plateletpheresis #Thresholds #NonBleeding #Surgery
Indications for Transfusion ... of Platelets in ... Peds #Pediatrics #Platelets ... #Transfusion #Plateletpheresis ... #Thresholds #NonBleeding
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 Indications for Transfusion Packed RBCs • Hgb <7 g/dL or hematocrit <21% in a patient with uncompromised
Indications for Transfusion ... hemoglobinopathy Platelets ... Platelet transfusions ... Willebrand disease #Transfusion ... #Indications #Thresholds
Thresholds for Transfusion of Platelets in Adults Major surgery or invasive procedure, no active bleeding - ≤
Thresholds for Transfusion ... of Platelets in ... #Management #Platelets ... #Transfusion #Plateletpheresis ... #Thresholds #NonBleeding
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 Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Transfusion Thresholds ... donor (apheresis) platelets ... Causes purpura & ... TRALI): Leading cause ... more likely to cause
Blood Product Components, Contents, Volume and Shelf Life Whole blood (autologous or directed donations) - RBC and
WBC and platelets ... Hct 60% Platelet ... pheresis - Platelets ... proteins, all coagulation ... @Bloodman #BloodProduct
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
incompatible blood transfusion ... Findings in DIC: • Platelet ... Thrombocytopenia - Platelet ... Treat primary cause ... #diagnosis #causes
Thromboelastography (trademarked as TEG) • Graphical representation of the fibrin polymerization process • Point-of-care anti-coagulation monitoring
Point-of-care anti-coagulation ... determining if transfusion ... reduce number of transfusions ... amplitude • If ↓ → platelet ... deficiency → give platelets
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
, due to anti-platelet ... Causes purpura & ... TRALI): Leading cause ... common following platelet ... more likely to cause
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Sequestration Disordered Platelet ... • Vasculitis Coagulation ... deficiencies Coagulation ... Diagnosis #Algorithm #Causes
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