129 results
diagnosis msk hematology management clinical radiology orthopedics workup mri endocrinology signs symptoms syndrome anemia hypercalcemia nephrology dermatology disease hepatology neurology
Paget's Disease of Bone • Characterized by an ↑ rate of bone turnover with both excessive
Paget's Disease of Bone ... and formation of bone ... • Caused by ( ... more (polystotic) bones ... pelvis, and long bones
Rheumatoid arthritis (RA): X-ray features • Soft tissue swelling (best seen by comparing left & right
Narrowing • Bony ... the articular bone ... Peri-articular osteopenia (bones ... Radiology #Clinical #Pathophysiology
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... Generally affects long bones ... • Differentiate ... BrighamChiefs #Bone ... #diagnosis #causes
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
excessive bone ... MSK • Deformed bones ... Lytic lesions make bones ... of middle ear bones ... PagetsDisease #pathophysiology
Hypercalcemia - Hormones and Pathophysiology Calcitriol: • Bones: Enhances mineralization • GI Tract: ↑ Ca2+
Calcitriol: • Bones ... PO4- PTH: • Bones ... : ↑ Bone resorption ... Calcitonin: • Bones ... : ↓ Bone resorption
Bone Lesion on X-Ray - Differential Diagnosis Algorithm Exostotic • Osteochondroma Asymptomatic &/or Non-Active Bone Scam •
Bone Lesion on X-Ray ... /or Non-Active Bone ... • Unicameral Bone ... • Aneurysmal Bone ... #Orthopedics #Causes
Primary Bone Tumors - Differential Diagnosis Algorithm Metastatic - Most common tumour in adults - Breast
Primary Bone Tumors ... - Differential ... • Aneurysmal Bone ... Histiocytoma #Primary #Bone ... #Orthopedics #Causes
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver, bone ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone ... Skeletal: - Bone
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Hypercalcemia - Differential ... Diagnosis Algorithm ... Miscellaneous - Bone ... Hyperthyroid, Bony ... #causes #endocrinology
Hyperparathyroidism - Primary vs Secondary vs Tertiary Lab Comparison: • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
signs, Fragile bones ... easily/weakness, Bone ... Secondary #Tertiary #pathophysiology
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