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rheumatology differential management erythematosus causes laboratory pulmonary systemic vasculitis alopecia antibodies antinuclear criteria dermatology disorders druginduced hairloss nephritis nephrology pathophysiology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... erythematosus (SLE ... • Nucleolar: Diffuse ... Antinuclear #Antibodies #ANA ... #rheumatology #diagnosis
Lupus Nephritis Primer Class I - Minimal Mesangial Class II - Mesangial Proliferative Class Ill - Focal Proliferative Class IV
Proliferative Class IV - Diffuse ... MD @MithuRheu and ... #Nephritis #SLE ... #Classification ... #differential #diagnosis
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... anticoagulant • Complement ... low C4, Low C3 and ... #Criteria #SLE ... Erythematosus #diagnosis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
vs SLE Drug Induced ... Workup: - ANA ... 90% - Low complement ... 80% - Low complement ... #rheumatology #diagnosis
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... Workup: - ANA ... 80% - Low complement ... Erythematosus #Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Skin Disease Classification ... Differential Diagnosis ... diffuse peritonitis
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... IMMUNOLOGIC CRITERIA - ANA ... anticoagulant - Low complement ... hemolytic anemia #Diagnosis ... #Rheumatology #SLE
Management of Lupus Nephritis Lupus nephritis (LN) in 10 to 40% of SLE Hallmark = proteinuria 20.5 g/g
in 10 to 40% of SLE ... severity (ISN/RPS classification ... by 12 months Classification ... • Class IV - Diffuse ... glomeruli) Diffuse
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
erythematosus (SLE ... erythematosus (SLE ... • Nucleolar: Diffuse ... (SLE), Systemic ... #rheumatology #diagnosis
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
- Differential Diagnosis ... Framework Diffuse ... anti-GBM) 10%: - Low Complement ... Levels: SLE, Cryoglobulinemic ... #Differential #Diagnosis
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