19 results
diagnosis differential management causes hematology copd hemolytic hus mechanical rheumatology treatment vasculitis ventilation workup aecopd anemia atypical breathing bronchiectasis c3
Atypical HUS - Hemolytic Uremic Syndrome Unlike typical HUS, which is shigatoxin mediated, aHUS is not typically
shigatoxin mediated, aHUS ... autoimmune like SLE ... It is complement ... renal, cardiac, pulmonary ... with Eculizumab (complement
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... Levels - C3, C4 • SLE ... • Infection eg SBE ... C3 ↓ C4 → • HUS ... ThePeanutKidney #Complement
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Pulmonary Renal ... anti-GBM) 10%: - Low Complement ... Levels: SLE, Cryoglobulinemic ... Vasculitis - Normal Complement ... Kumfer @AnnKumfer #Pulmonary
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... With associated pulmonary ... differential #diagnosis #algorithm
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... genotypes): SS, SC, SE ... DIC, TTP, HELLP, HUS ... , aHUS, mechanical ... Differential #Diagnosis #Algorithm
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
is due to TTP, compliment-mediated ... TTP (atypical HUS ... ), Shiga-toxin HUS ... catastrophic APS, SRC, SLE ... diagnosis #ttp #hus
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Differential Diagnosis Algorithm ... perfringens - Complement-Mediated ... MAHA (TTP, DIC, HUS ... Differential #Diagnosis #Algorithm
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Differential Diagnosis Algorithm ... Autoimmune • ITP • SLE ... Syndrome • TTP/HUS ... Differential #Diagnosis #Algorithm
Bronchiectasis: diagnosis and management Causes of localized -> diffuse bronchiectasis Foreign body, Bronchial stenosis (tumor, .. ),
RA, Sjögren, SLE ... Differential #workup #algorithm ... #pulmonary
Causes of Pleural Effusion - Differential Diagnosis Algorithm Exudative Effusion: - Pulmonary •
Differential Diagnosis Algorithm ... Effusion: - Pulmonary ... Inflammatory (RA, SLE ... ) • Pulmonary ... Differential #Diagnosis #Algorithm
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