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diagnosis hematology algorithm oncology dermatology disorders thrombocytopenia secondary systemic treatment bruising cardiology chronic eosinophilia generalized hemeonc hemolytic lymphocytic macrocytic mds
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Hematology #Oncology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... Chronic inflammatory disorders ... Myelodysplastic syndrome ... Chronic myeloid leukemia ... (CML) - Dr.
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Hyperuricemia - Differential ... Lymphoproliferative Disorders ... Anemia - Others ... Diagnosis #Algorithm #endocrinology ... #causes
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... lymphoproliferative disorders ... • Neutropenia, anemia ... • Richter’s Syndrome ... syndrome • Smoldering
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... ITP • SLE • CLL ... Non-lmmune: • HELLP Syndrome ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Artifact (redo CBC ... Chronic Myelogenous Leukemia ... • Rheumatic disorders ... Iron deficiency anemia ... #Hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Basophilia - Differential ... Myeloproliferative Disorders ... Chickenpox Other Causes ... #Diagnosis #causes ... #hematology #basophils
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... changes), high MCV anemia ... not required in all ... #Differential # ... #Workup #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute leukemia ... Allogeneic stem cell
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
(CLL) - Summary ... in adults • Disorder ... 5) Symptoms of anemia ... #oncology #hematology ... hemeonc #diagnosis #management
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