12 results
diagnosis differential causes coagulation laboratory thrombocytopenia abnormal acronym aflp aptt bleeding bruising deficiencies deficiency dermatology disorders disseminated hellp hemolysis hemolytic
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) Prothrombin Time (PT) - Often Elevated in: • Vitamin
inhibitor • Liver ... disease Partial ... elevated in: • Heparin ... elevated in: • DIC ... Thromboplastin #laboratory #hematology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
Laboratory Findings in Hepatic ... disease, ALT and ... - Prolonged PT ... As a result of DIC ... #Hepatology #Laboratory
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Medications - Heparin ... ) • Advanced Liver ... Post-partum • Acute DIC ... Summary #table #comparison ... #diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Extrinsic Causes: • Liver ... disease • Hypersplenism ... MAHA: TTP, HUS, DIC ... Diagnosis #causes #classification ... #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
MAHA: TTP, HUS, DIC ... Defects, Drugs, Liver ... Defects: Sickle cell anemia ... Dehydrogenase ↑ - Peripheral ... Differential #Diagnosis #hematology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Liver Disease in ... DIC • Aminotransferases ... #Disease #Pregnancy ... #hepatology #obstetrics ... #hepatitis #comparison
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... D-Dimer: ↑ • Peripheral ... • Severe Liver ... Disease: - Impaired ... treatment #management #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- DIC/TTP/HUS ... - Hemolytic anemia ... deficiency • Liver ... Cholesterol emboli • Septic ... Differential #Diagnosis #hematology
PLATELETS Mnemonic for Causes of Thrombocytopenia P - Platelet Disorders (DIC, ITP, TTP) L - Leukemia, Lymphoma A -
Platelet Disorders (DIC ... A - Aplastic Anemia ... Enlarged Spleen L - Liver ... Disease, Lab error ... Differential #Diagnosis #Hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... unfractionated heparin ... Reduced liver synthesis ... intravascular coagulation (DIC ... #differential #hematology
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