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diagnosis differential hematology treatment algorithm acute hemeonc hemophagocytic hlh leukemia lymphohistiocytosis peds activation agglutinin anemia autoimmune behcet cerebritis chronic classification
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... involvement • 30%: CNS ... : Blast crises ... : CNS manifestations ... #Oncology #Diagnosis
Naloxone for Clonidine Overdose Indication: Altered mental status, CNS depression or respiratory depression due to clonidine overdose Dosing:
mental status, CNS ... IV push all at ... them may improve CNS ... Naloxone may improve CNS ... Overdose #toxicology #management
Multiple Cranial Neuropathies - High Yield Differential Diagnosis • Intrinsic brainstem process • Compressive brainstem process
Neurosarcoidosis • CNS ... Lyme Disease, TB ... Miller Fisher Syndrome ... variant-GBS • Bulbar ALS ... Differential #Diagnosis #causes
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
antibiotics TLS ... low Ca - q8 h TLS ... Treat underlying cause ... ) - Symptoms: CNS ... ) - Symptoms: CNS
Treatment Schema for Standard-Risk Acute Lymphoblastic Leukemia Induction: • Vincristine, Steroid (dexamethasone), L-Asparaginase, Intrathecal (IT) methotrexate Consolidation
Consolidation & CNS ... Cytarabine #ALL ... Treatment #timeline #oncology ... #pediatrics #peds ... #management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... • Heavy Chain disease ... Scleromyxedema (CNS ... Sneddon-Wilkinson disease ... Differential #Diagnosis #Oncology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Demyelinating Syndrome ... Cerebrovascular Disease ... Erythematosus #SLE #CNS ... #neurology #rheumatology
Acute and Chronic Causes of Dyspnea - Differential Diagnosis Pulmonary/Chest Wall: • Acute: Trauma, COPD exacerbation, Asthma
Acute and Chronic Causes ... Pulmonary/Chest Wall ... hernia, Obesity CNS ... Encephalitis • Chronic: ALS ... Acute #Chronic #Causes
Hypoxemia / Hypoxia - Rapid Response Management Algorithm Stridor - Upper airway pathology: • Anaphylaxis • Foreign
Rapid Response Management ... asthma • Pleural disease ... Hypoventilation: • CNS ... e.g., GBS, MG, ALS ... differential #Diagnosis #Management
Differential diagnoses for the neuro-ophthalmologic finding of diplopia. Neoplastic: • Intraorbital meningioma • Pituitary adenoma
Sphenoid sinusitis (CN ... Miller-Fisher syndrome ... intracranial pressure (CN ... hypertension (CN ... Differential #Diagnosis #Causes
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