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differential causes oncology workup pancytopenia classification management elevatedmcv hemolytic macrocytic macrocytosis mcv mds microcytic myelodysplastic aion anemias anteriorischemicopticneuropathy approach b12
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
- Differential Diagnosis ... Algorithm Decreased ... • Marrow Aplasia ... (MAHA) - Abnormal ... #Hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
- Differential Diagnosis ... Algorithm Sequestration ... • Toxins • Aplastic ... Anemia • Myelodysplasia ... #Hematology
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential Diagnosis ... Algorithm Signs ... Reticulocytes • Abnormal ... #Differential #Diagnosis ... #Algorithm #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... syndrome (MDS) (normal ... megakaryocytes and a normal ... #hematology #diagnosis
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... Diagnosis Framework ... Non-hemolytic: ACD, Aplastic ... #MCV #Algorithm ... #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Algorithm Blood ... RBC Production - Normal ... Deficiency • Aplastic ... #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... Algorithm Normal ... Macrocytosis, Target Cells ... #Algorithm #Causes ... #Hematology
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Algorithm Features ... of hematologic ... hepatomegaly • Labs: anemia ... predominant immature cells ... #Algorithm #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential Diagnosis ... Algorithm Decreased ... Megakaryopoiesis • Aplastic ... Anemia • Toxic ... #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
marrow) -dys- (abnormal ... ) -plastic (shape ... = funny-shaped cells ... cytopenias (usually anemia ... Management #treatment #hematology
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