16 results
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... et diutinum Neurologic ... vascular beds-renal ... #Differential #Diagnosis ... #Oncology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
- Differential Diagnosis ... Neurologic-Centered ... Cryoglobulinemia Renal-centered ... Ig deposition disease ... #hematology #oncology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
dL the ULN R - Renal ... disease - Cr >2 ... plasmacytoma, POEMs syndrome ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
LC deposition disease ... tubulopathy • Monoclonal ... gammopathy of renal ... #AKI #Cancer #Oncology ... #Differential #Diagnosis
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
ulceration • Ocular ... skin injury) • Neurologic ... basal ganglia, CNS ... meningitis), MCC CNS ... : monoclonal TNF-aIpha
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
desaturation, Scotoma, Ocular ... (AQP4-lgG disease ... pain • Extra-CNS ... Manifestations #diagnosis ... #neurology #symptoms
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
- Differential Diagnosis ... inhibitors, hepatorenal syndrome ... thromboembolism, renal ... : Disease process ... #nephrology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
rheumatoid arthritis, monoclonal ... (Dense deposit disease ... anti-phospholipid syndrome ... Glomerulonephritis #MPGN #nephrology ... #diagnosis #renal
Ptosis - Differential Diagnosis Framework

Ptosis (Greek- to fall) Drooping of the upper eyelid that usually results
- Differential Diagnosis ... CN III palsy 2. ... Neurogenic Ptosis - Neurologic ... disease affecting ... #Ptosis #neurology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Diagnosis: • Dry ... gland) biopsy • Ocular ... • 8%-27% for CNS ... cirrhosis: 3%-20% Renal ... Distal (Type I) renal