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differential neurology hematology causes erythematosus management systemic signs sle symptoms clinical ana antibodies antinuclear myopathy myositis table vasculitis video anisocoria
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
Other brainstem syndromes ... • Transverse myelitis ... pain • Extra-CNS ... disorders (Systemic lupus ... Manifestations #diagnosis
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Demyelinating Syndrome ... permeability Diagnosis ... Erythematosus #SLE #CNS ... #neurology #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... LAC) • Sjogren Syndrome ... Peptide (CCP) • Myositis ... #diagnosis #associations
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Myositis and Myopathies ... Anti-retrovirals, Gemcitabine Lupus ... uncommon 5-15% of lupus ... #differential #diagnosis ... #comparison #rheumatology
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
BEE Syndromes - ... nervous system (CNS ... important, as early diagnosis ... • Systemic lupus ... #differential #diagnosis
Differential diagnoses for the neuro-ophthalmologic finding of diplopia. Neoplastic: • Intraorbital meningioma • Pituitary adenoma
Differential diagnoses ... for the neuro-ophthalmologic ... Miller-Fisher syndrome ... #Differential #Diagnosis ... #Causes #Ophthalmology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Homogeneous: Systemic lupus ... , Drug-induced Lupus ... SLE), Sjogren's Syndrome ... ANA #patterns #rheumatology ... #diagnosis #differential
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Myositis Specific ... Anti-Synthetase Syndrome ... Inclusion Body Myositis ... MSAs #clinical #diagnosis ... #rheumatology #
Hypertension and Altered Mental Status (AMS) - Differential Diagnosis Framework Hypertension: • Hypertensive emergency • Hypertensive encephalopathy
- Differential Diagnosis ... • Cushing’s syndrome ... Hyperthyroidism CNS ... /agitation • CNS ... Vasculitis • Lupus
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Demyelinating syndromes ... Glomerulonephritis Myositis ... signs #symptoms #diagnosis ... #rheumatology
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