99 results
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... heliotrope rash, Shaw sign ... , holster sign, ... /full triad at diagnosis ... #diagnosis #rheumatology
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Myositis Specific ... Inclusion Body Myositis ... Antibodies #MSAs #clinical ... #diagnosis #rheumatology ... #table
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... Peptide (CCP) • Myositis ... Autoantibodies #Rheumatology ... #diagnosis #associations ... #table
Systemic Sclerosis (Scleroderma)
Limited - CREST:
 • Calcinosis
 • Raynaud phenomenon
 • Esophageal dysmotility
 • Sclerodactyly
 •
involve DIP • Myositis ... Ann Marie Kumfer ... #Scleroderma #diagnosis ... #signs #symptoms ... #rheumatology
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
Optica (NMO) - Clinical ... • Transverse myelitis ... pain • Extra-CNS ... Manifestations #diagnosis ... neurology #symptoms #signs
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
heliotrope, shawl sign ... Pattern: Proximal and ... #differential #diagnosis ... #comparison #rheumatology ... #table
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
- Differential Diagnosis ... pulmonary etc) • CNS ... -> PNS -> NMJ - ... Lack of UMN/LMN signs ... #Differential #Diagnosis
Beevor's Sign on Physical Exam

Beevor's sign is abnormal upward (cephalad) movement of the umbilicus with truncal
Beevor's Sign on ... Exam Beevor's sign ... dystrophy (FSHD) and ... inclusion body myositis ... PhysicalExam #clinical
Clinical Manifestations of Serotonin Syndrome
 • Ophthalmologic: Mydriasis, Ocular clonus (slow horizontal movements)
 • Gastrointestinal: Diarrhea,
Clinical Manifestations ... Diaphresis, flushing • CNS ... Cardiovascular and ... vital sign abnormalities ... #diagnosis
Lelli's Test (Lever Sign) for ACL Injury

A fist is placed under the proximal 3rd of the
Lelli's Test (Lever Sign ... 3rd of the calf and ... rises from the table ... cruciate #ligament #clinical ... #video #physicalexam