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differential hematology management autoantibodies disease erythematosus lupus systemic activation agglutinin algorithm altered anemia antibodies antinuclear autoimmune behcet blood causes cerebritis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... Anti-mitochondrial (AMA ... Anti-Scl-70 - Scleroderma ... #diseases #diagnosis ... #table #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... LAC) • Sjogren Syndrome ... TIF1y, MDA5 • Scleroderma ... #diagnosis #associations ... #table
Hypertension and Altered Mental Status (AMS) - Differential Diagnosis Framework Hypertension: • Hypertensive emergency • Hypertensive encephalopathy
Hypertension and ... - Differential Diagnosis ... • Cushing’s syndrome ... /agitation • CNS ... Polyarteritis nodosa • Scleroderma
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Asia • HLA-B51 association ... basal ganglia, CNS ... meningitis), MCC CNS ... Reactive Arthritis, AS ... signs #symptoms #rheumatology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Disorders - Markers and ... Differential Diagnosis ... Lymphadenopathy, CNS ... Blood #Disorders #hematology ... #Differential #Diagnosis
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
searched for when ANA ... SLE-SSc-AlM overlap syndromes ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Demyelinating Syndrome ... permeability Diagnosis ... (for secondary APS ... #neurology #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... Periodic fever syndromes ... nervous system (CNS ... #Diagnosis #Management ... #Hematology #Rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... develop leukostasis syndrome ... : CNS manifestations ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Bernard-Soulier Syndrome ... Grey Platelet Syndrome ... Defects #comparison #table ... #differential #diagnosis ... #hematology
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