8233 results
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Pathogenesis and clinical ... mutated in one cell ... mutated in all cells ... Retinoblastoma Signs ... ophthalmology #diagnosis #signs
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Physical Exam/Signs ... smear: Smudge cells ... or basket cells ... disease • B cell
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Pathogenesis and Clinical ... B and CD-4+ T cells ... CRP Neuronal cell ... surface targeted -> Cell ... pathophysiology #diagnosis #signs
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
Pathogenesis and clinical ... Signs of immunodeficiency ... involved in B cell ... -> Impaired B cell ... humoral immunity Signs
Here are the morphological hallmarks of Rhabdomyosarcoma.

 - Broken arrow sign 

 - tad-pole rhabdomyoblasts
- Broken arrow sign ... rhabdomyoblasts - Wraith cells ... Pathology #Microscopy #Clinical
Tree in Bud Sign
The Tree-in-Bud sign represents Endobronchial spread in a linear branching pattern and centrilobular
Tree in Bud Sign ... The Tree-in-Bud sign ... bronchioalveolar cell ... Bud #TreeInBud #Sign ... #diagnosis #clinical
Multiple Myeloma Diagnosis and Management Summary
Clinical Signs:
 • hyperCalcemia 28% (bone demineralization)
 • Renal disease 48%
Management Summary Clinical ... Signs: • hyperCalcemia ... marrow plasma cells ... plasma clonal cell
Differential diagnosis of Langerhans cell histiocytosis.
Nodular LCH:
- Sarcoidosis: perilymphatic distribution.
- Metastases: random distribution.
Cystic LCH:
- LAM: round
of Langerhans cell ... : 'signet ring sign ... central dot. - LIP #Clinical
Giant Cell (Temporal) Arteritis: Clinical findings and Complications
Signs/Symptoms: 
 - Headache (usually constant, superimposed by waves
Giant Cell (Temporal ... ) Arteritis: Clinical ... Complications Signs ... Complications #Signs
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
Pathogenesis and Clinical ... commonly hairy-cell ... vascular endothelial cells ... Pathophysiology #Diagnosis #Signs