44 results
Compelling and Possible Contraindications to Antihypertensive Drugs
Diuretics (thiazides)
 - Gout
 - Metabolic syndrome, Glucose intolerance, Pregnancy,
, Bilateral renal ... , Bilateral renal ... potential Ca2+ channel ... failure Ca2+ channel ... contraindications #table
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
Drugs that Impair Renal ... Decreased ENaC channel ... happypillsrx/ #Hyperkalemia ... #Pathophysiology ... #Pharmacology #
BRASH Syndrome

B - Bradycardia
R - Renal failure
A - AV nodal blockade
S - Shock
H - Hyperkalemia

Typical ECG
Bradycardia R - Renal ... S - Shock H - Hyperkalemia ... Typical ECG ... • If on a Ca2+ channel ... diagnosis #management #pathophysiology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... Heparin) • Sodium-channel ... • Increased EC ... differential #diagnosis #pathophysiology ... #pharmacology #
Etiologies of Hypernatremia - Differential Diagnosis
GI losses / Insensible losses
Sodium Overload
Transcellular Movement of Water
Central Diabetes Insipidus
cisplatin) - Chronic hypercalcemia ... - Chronic hypokalemia ... - Various renal ... renal amyloidosis ... Differential #Diagnosis #Table
Hyperkalemia shortens repolarization; changes in the T wave provide the earliest clues to hyperpotassemia.
 - At
Hyperkalemia shortens ... repolarization; changes ... #Diagnosis #Hyperkalemia ... #EKG #ECG #Changes ... #Progression #Table
NSAIDS and their effects on the Kidney - Pathophysiology

Arachidonic Acid metabolites into alternative pathways that modify
on the Kidney - Pathophysiology ... function • Minimal Change ... hyporenin hypoaldo, hyperkalemic ... nephrology #Effects #pathophysiology ... #renal
Checklist Approach to Hypokalemia

Consider risk factors for arrhythmia:
 - EKG changes (especially QT prolongation)
 - Digoxin
Checklist Approach to Hypokalemia ... changes (especially ... 3.5 - Severe renal ... monitoring depend on renal ... monitoring depend on renal
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Agents to Treat Hyperkalemia ... to moderate); hypokalemia ... • Mechanism: Exchanges ... #medications #pharmacology ... #table #comparison
Emergent Hyperkalemia Treatment Algorithm
ECG changes, weakness, K+ >6.5 Or renal insufficiency with K >5.5 with cellular
Emergent Hyperkalemia ... Treatment Algorithm ECG ... changes, weakness ... , K+ >6.5 Or renal ... changes?