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diagnosis differential hematology causes systemic extravascular generalized hemolysis intravascular pruritus workup agglutinin aiha atlas autoimmune blood bloodcell common cvid disease
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
(sometimes) Macrocytic ... Unstable hemoglobin disorders ... Agglutinate: Cold ... cold hemoglobinuria ... differential #diagnosis #hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Differential Diagnosis Algorithm ... Pseudo Pelger-Huet, Macrocytic ... anemia - ... • Lymphoid (CLL ... #hematology #Markers
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Differential Diagnosis Algorithm ... Hypersplenism • Secondary ... Polychromatic Macrocytes ... Bleed • Hemolysis ... #Causes #Hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Algorithm Mean ... acute blood loss, hemolysis ... (BM) ablative disorders ... #Workup #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
AIHA Primary Secondary ... Secondary Cold ... • Symptoms of anemia ... anemia • Cold ... #anemia #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... ) (e.g. lupus, CLL ... (e.g. primary cold ... lymphoproliferative disorders ... #anemia
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Differential Diagnosis Algorithm ... • Starvation Secondary ... Lymphoproliferative Disorders ... (CML) - Hemolytic ... Anemia - Others
Autoimmune Hemolytic Anemia (AIHA) WARM AHA - Primary - Idiopathics - Secondary Infectious • Viral- HIV, EBV, HCV, HEV •
Autoimmune Hemolytic ... Anemia (AIHA) ... alpha-methyldopa COLD ... #Anemia #AIHA # ... #Differential #Algorithm
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Differential Diagnosis Algorithm ... Warm AIHA • Cold ... • Sickle cell ... anemia • ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... iron deficiency, hemolysis ... Chronic inflammatory disorders ... Chronic myeloid leukemia ... (CML) - Dr.
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