889 results
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease
Increased Thrombosis 
Increased Platelet-Vesset Wall Interaction 
 •
Thrombosis #Bleeding #Clot ... #Cirrhosis #Pathophysiology
Tranexamic Acid: Mechanism of Action
 - TXA is an anti-fibrinolytic
 - TXA is a synthetic analog
the fibrin-rich clot ... Tranexamic #Acid #pathophysiology
Lemierre’s Syndrome - Pathophysiology

Lemierre’s is an infectious thrombophlebitis of the internal jugular vein.

 - It starts
Lemierre’s Syndrome - Pathophysiology ... bacteremic and a clot ... Lemierres #Syndrome #Pathophysiology
D-dimer
Plasma D-dimer is a product of clot breakdown, released upon degradation of polymerized, crosslinked fibrin. Elevated
is a product of clot ... activated, fibrin clot ... has formed, & clot ... Ddimer #dimer #pathophysiology
Fibrinolysis. 
Fibrinolysis occurs when plasminogen is activated to plasmin under the influence of factors such as
to dissolve the clot ... Fibrinolysis #Pathway #Pathophysiology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
platelet #thrombin #clot ... models #hematology #pathophysiology
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but potentially serious adverse reaction that has been
formation of blood clots ... thrombocytopenia #COVID #pathophysiology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... significant fibrin clot
THROMBOELASTOGRAPHY (TEG)
General Principle
• A small cuvette is rotated to simulate sluggish venous flow and stimulate clot
and stimulate clot ... the mass of the clot ... the kinetics of clot ... information about clot ... latency until clot
Normal Thromboelastogram - Specific parameters represent the 3 phases of the cell-based model of haemostasis: initiation,
certain level of clot ... assesses the rate of clot ... of the fibrin clot ... stability of the clot ... = clot lysis time