13 results
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Coagulation Cascade ... twitter.com/AmyChung #AntiCoagulation ... #Cascade #Anticoagulants ... #Pharmacology #Pathophysiology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... #Coagulation #Cascade ... clot #PT #PTT #diagnosis ... models #hematology #pathophysiology ... #anticoagulation
Hemostasis Physiology

The blood's response to blood vessel injury can be viewed as four interrelated steps. 
Roman
numerals refer to coagulation ... diphosphate; PF-3, platelet ... #Hemostasis #Pathophysiology ... #Coagulation #Cascade
Thromboelastogram Interpretation
Reaction Time (R Value):
 - Time till initiation of fibrin clot
 - Treatment: FFP, protamine
K
Thromboelastogram Interpretation ... representing thrombin-platelet ... - Treatment: Platelets ... Thromboelastography #diagnosis ... #coagulation #hematology
Bleeding and Bruising - Differential Diagnosis Algorithm
 • Vascular System Defect - Congenital vs Acquired
 •
- Differential Diagnosis ... vs Acquired • Platelet ... Qualitative • Coagulation ... #Differential #Diagnosis ... #Algorithm #pathophysiology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
- Differential Diagnosis ... Sequestration Disordered Platelet ... • Vasculitis Coagulation ... - Acquired • Anticoagulation ... #Differential #Diagnosis
THROMBOELASTOGRAPHY (TEG)
General Principle
• A small cuvette is rotated to simulate sluggish venous flow and stimulate clot
problems with coagulation ... cascade and platelet ... Thromboelastography #Diagnosis ... CriticalCare #Hematology #Interpretation
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation ... protein C and S Pathophysiology ... Findings in DIC: • Platelet ... Thrombocytopenia - Platelet ... #diagnosis #causes
Management of Jehovah's Witness patient in ICU 

Clarify which products may be used 
 - Discuss
- When anticoagulation ... - Be aware of coagulation ... periodically check platelets ... twitter.com/PulmCrit #Checklist
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
- Differential Diagnosis ... Qualitative defect in platelets ... characteristic of a platelet ... inhibitor of a coagulation ... integrity Clotting cascade