18 results
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
presents with coagulation ... pregnancy * Severe coagulation ... AFLP #obstetrics #hematology ... #diagnosis #table ... #comparison
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
presents with coagulation ... pregnancy * Severe coagulation ... Obstetrics #OBGyn #Hematology ... #Diagnosis #Comparison ... #Table
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Summary of Coagulation ... ) • Advanced Liver ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
- Differential Diagnosis ... Destruction • Abnormal ... Iatrogenic) • Liver ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
- Differential Diagnosis ... inhibitor of a coagulation ... integrity Clotting cascade ... #Differential #Diagnosis ... #Hematology
Appearance of Liver Lesions on Various Imaging Modalities
 • Computed Tomography (CT) - Arterial Phase, Portal
Appearance of Liver ... Contrast #CT #MRI #POCUS ... #differential #diagnosis ... #comparison #table ... #appearance #hepatology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... Prolonged #Causes #diagnosis ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Thrombocytopenia - Normal ... DIC • Severe Liver ... - APTT < 1.5 x normal ... #diagnosis #causes ... treatment #management #hematology
CHA2DS2VASc vs HAS-BLED scores for stroke risk and bleed risk on anticoagulation

C	Congestive Heart Failure	1

H	Hypertension	1

A2	Age >75	2

D	Diabetes Mellitus	1

S2	Stroke,
hypertension 1 A Abnormal ... >2.3mg/dL) 1 Liver ... CHADS2VASc #HASBLED #Comparison ... Anticoagulation #AFib #Diagnosis ... #Hematology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
- If both are normal ... • Albumin • Coagulation ... of ALP • Near normal ... #chemistry #diagnosis ... #differential #Hepatology