5784 results
Effect of Selected Diseases on Complement Levels - C3, C4
 • SLE C3 ↓ C4 ↓↓
• SLE C3 ↓ C4 ... MCGN type 1 C3 ↓ C4 ... ↓↓ • Cryo C3 ... #differential #diagnosis ... #c4 #c3
Glomerulonephritis - Differential Diagnosis Framework
ANCA:
 • C-ANCA: GPA (Wegener's)
 • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
- Differential Diagnosis ... Membranoproliferative • ↓C4 ... Cryoglobulinemia • Normal C3/C4 ... #differential #diagnosis
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
- Differential Diagnosis ... , Anti-GBM, C3/C4 ... #Differential #Diagnosis
Diagnosis and Management of Hypocomplementemic Urticarial Vasculitis (HUV)

Diagnosis of HUV
1) Chronic urticaria 
2) Leukocytoclastic vasculitis 
3)
Diagnosis and Management ... Vasculitis (HUV) Diagnosis ... Hypocomplementemia (C3 and/or C4 ... Vasculitis #HUV #Diagnosis
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Low C3 or low C4 ... Low C3 and low C4 ... Erythematosus #diagnosis
Subtypes of Serum Proteins

Pre-albumin (Transthyretin)
Albumin
Globulins
 • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
• Beta: C3 and C4
Formation of Trunks and Cords of the Brachial Plexus
The spinal nerves of segments C5 – Th1
also of segments C4
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
decr of C3 and C4 ... min/1.73 m2 at diagnosis ... • Dialysis at diagnosis
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Differential Diagnosis ... anti-GBM ab, ANA, C3, C4 ... #differential #diagnosis
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... complement (C3, C4 ... hemolytic anemia #Diagnosis