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diagnosis causes algorithm nephrology management pulmonary clinical table cardiology radiology hematology neurology dermatology workup ddxof pediatrics infections endocrinology classification comparison
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
• SLE C3 ↓ C4 ... MCGN type 1 C3 ↓ C4 ... ↓↓ • Cryo C3 ... angiooedema C3 C4 ... #differential #
Glomerulonephritis - Differential Diagnosis Framework ANCA: • C-ANCA: GPA (Wegener's) • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Glomerulonephritis - Differential ... Membranoproliferative • ↓C4 ... Cryoglobulinemia • Normal C3/C4 ... Glomerulonephritis #differential
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Injury (AKI) - Differential ... , Anti-GBM, C3/C4 ... Kidney #Injury #Differential
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Algorithm and Differential ... blood count with differential ... Anti-ds-DNA, C3/C4 ... Workup #Algorithm #Differential
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
symptomatology Differential ... anti-GBM ab, ANA, C3, C4 ... Renal #Syndrome #differential
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
• Beta: C3 and C4
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Low C3 or low C4 ... Low C3 and low C4
Formation of Trunks and Cords of the Brachial Plexus The spinal nerves of segments C5 – Th1
also of segments C4
Spinal Cord Injury by Nerve Root Levels Spinal Root Sensory Motor Reflex C4 Acromioclavicular Joint Respiration None C5 Radial Antecubital Fossa Elbow Flexion Biceps Reflex C6 Dorsal Thumb Wrist Extension Brachioradialis Reflex C7 Dorsal
Motor Reflex C4 ... NerveRoots #Levels #differential
Diagnosis and Management of Hypocomplementemic Urticarial Vasculitis (HUV) Diagnosis of HUV 1) Chronic urticaria 2) Leukocytoclastic vasculitis 3)
Hypocomplementemia (C3 and/or C4
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