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diagnosis differential lupus rheumatology erythematosus classification hematology clinical criteria disorders management nephrology pathophysiology table vasculitis allergy arthropathies arthropathy avs biopsy
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... • SLE C3 ↓ C4 ... ↓ C4 ↓↓ • Cryo ... • Infection eg SBE ... ThePeanutKidney #Complement
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Classification Criteria for Systemic ... anticoagulant • Complement ... or low C4, Low C3 ... Classification #Criteria #SLE ... #Systemic #Lupus
Systemic Lupus Erythematosus (SLE): Pathogenesis • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Systemic Lupus Erythematosus ... (SLE): Pathogenesis ... HLA-DR3 genes, complement ... self-antigens, activating complement ... Erythematosus #SLE
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... Criteria - Systemic ... anticoagulant - Low complement ... (C3, C4, or CH50 ... #Rheumatology #SLE
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Cryoglobulinemia (85%), C3 ... glomerulonephritis (>90%) S - Systemic ... Hypocomplementemia #Low #Complement
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... are evocative of SLE ... 80% - Low complement ... #lupus #Systemic
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... RNP antibodies, Complement ... levels (C3 and ... disease activity • C3
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus vs SLE ... 90% - Low complement ... months to years) Systemic ... Erythematosus (SLE ... 80% - Low complement
Approach to managing Glomerulonephritis (GN) in children. ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
cytoplasmic antibodies; SLE ... , systemic lupus ... Glomerulonephritis #Algorithm
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Neurologic-Centered: (+) Systemic ... Cryoglobulinemia (-) Systemic ... Cutaneous-centered: • Systemic ... immunotactoid GN, Type I cryo ... monoclonal Ig deposits, C3
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