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Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Cryoglobulinemia ... peripheral neuopathy, pulmonary ... MatthewHoMD #Cryoglobulinemia
Small Vessel Vasculitides • Granulomatosis with polyangiitis - Granulomatous manifestations (e.g., nasal crusting, destructive sinusitis, pulmonary
destructive sinusitis, pulmonary ... involvement • Cryoglobulinemic
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Pulmonary Renal ... Complement Levels: SLE, Cryoglobulinemic ... Kumfer @AnnKumfer #Pulmonary
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Presentation (Pulmonary ... Diagnosis for Pulmonary ... Behcet disease, Cryoglobulinemia ... @PulmPEEPs #Pulmonary
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Lupus Nephritis, Cryoglobulinemia ... With associated pulmonary
Hemoptysis - Differential Diagnosis Framework Massive Hemoptysis: >150-300 mL in 24h Airway disease: • Bronchitis, Bronchiectasis, Malignancy
> EGPA, MPA), Cryoglobulinemia ... Differential #Diagnosis #pulmonary
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
progressing GN • New pulmonary ... glomerulonephritis and/or pulmonary ... ANCA +MPO) • Cryoglobulinemic ... arthritis, obstructive pulmonary ... Low levels mixed cryoglobulinemia
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
vasculitis, sepsis or cryoglobulinemia ... thrombophlebitis, pulmonary ... Calciphylaxis • Cryoglobulinemia
Treatment of Non-hepatitis C virus Cryoglobulinemia Vasculitis - French Vasculitis Study Group MONOCLONAL CRYOGLOBULINEMIA (TYPE 1) IgM
Non-hepatitis C virus Cryoglobulinemia ... MONOCLONAL CRYOGLOBULINEMIA ... lenalinomide MIXED CRYOGLOBULINEMIA ... TerrierBen #NonHCV #Cryoglobulinemia ... Monoclonal #Mixed #Cryoglobulinemic
Diagnosis of Cryoglobulinemia Vasculitis 1) Presence of cryoglobulin Circulating immunoglobulins that precipitate with cold temperature and dissolve
Diagnosis of Cryoglobulinemia ... ) MONOCLONAL CRYOGLOBULINEMIA ... syndrome MIXED CRYOGLOBULINEMIA ... TerrierBen #Cryoglobulinemia ... #Rheumatology #Cryoglobulinemic
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