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diagnosis anemia differential autoimmune hemolysis causes oncology rheumatology treatment agglutinin algorithm antiglobulin behcet chronic copd cryofibrinogenemia dat direct extravascular gold2022
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
(48-70%) Cold ... HA (paroxysmal cold ... hemoglobinuria) • Cold ... Agglutinin Disease ... Diagnosis #Table #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
- Autoimmune (AIHA ... - Autoimmune (AIHA ... )"Cold" (usually ... (e.g. primary cold ... differential #diagnosis #hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Autoimmune Hemolytic ... esp if severe disease ... azathioprine Cold ... Treatment #management ... #hematology
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
), C3d ( - ) WAIHA ... , C3d ( +/- ) Cold ... agglutinin disease ... ) Paroxysmal cold ... #hematology #diagnosis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin ... of Cold Sensitive ... Cold Agglutinins ... women • 15% of AIHA ... #hematology #diagnosis
Chronic Obstructive Pulmonary Disease (COPD) • COPD Definition • Role of PFTs • COPD Classification and
Chronic Obstructive Pulmonary ... Disease (COPD) ... Classification ... #Disease #COPD ... #diagnosis #management
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Causes: • Liver disease ... Hypersplenism • AIHA ... : warm, cold, drug ... Diagnosis #causes #classification ... #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Autoimmune: Warm AIHA ... , Cold AIHA, Transfusion ... , Drugs, Liver Disease ... Differential #Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle cells ... Consider sickle cell disease ... Agglutination - Cold ... Algorithm #workup #hematology
Pulmonary Hypertension Groups - WHO Classification Group I - Vascular remodeling of pulmonary arteries • Idiopathic, HIV,
Groups - WHO Classification ... hypoxemia • COPD ... Sarcoidosis, chronic hemolytic ... PH Functional Classification ... #Groups #WHO #Classification
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