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diagnosis differential algorithm hematology causes management clinical signs symptoms workup neurology pathophysiology hemolytic cardiology nephrology deficiency pediatrics pharmacology mnemonic physicalexam
Approach to Antithrombotic Therapy in Peripheral Artery Disease Increased Ischemic Risk: • Prior MI • Diabetes •
kidney disease • Anemia ... management #therapy #dapt
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... blood smear + DAT ... → Sickle Cell anemia ... Microangiopathic hemolytic anemia ... UnremarkableLab #Hemolytic #Anemia
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Causes of Hemolytic Anemia ... - Antibody/DAT ... - Complement/DAT ... #Hemolytic #Anemia
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic Anemia ... IgG mediated - DAT ... IgM mediated - DAT ... Autoimmune #Hemolytic #Anemia
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic Anemia ... Mixed-type AIHA (7-8%) DAT-negative ... Autoimmune #Hemolytic #Anemia
Differential Diagnosis of Anemias #Diagnosis #IM #Honc #Anemia #Differential #Iron #Algorithm #Microcytic #Macrocytic #Normocytic #Ddxof
Differential Diagnosis of Anemias ... Diagnosis #IM #Honc #Anemia
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... Autoimmune Hemolytic Anemias ... Alloimmune Hemolytic Anemias ... #Hemolytic #Anemias
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
Expected DAT Results ... Autoimmune Hemolysis DAT ... Hemolysis • DAT ... - ) WAIHA • DAT ... hemoglobinuria • DAT
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... Microangiopathic Hemolytic Anemia ... iron deficiency anemia ... Autoimmune hemolytic anemia ... autoimmune hemolytic anemia
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
breakdown • Anaemia ... Hemolysis #Hemolytic #Anemia
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